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Ampicillin and Sulbactam Essay

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Pregnancy Category: B| Bactericidal action. Active against: Streptococci,Penumococci,Enterococci,Haemophilus influenzae. Binds to bacteria cell wall, resulting in cell death, spectrum is broader than that of penicillin. Addition of sulbactam increases resistance to beta-lactamase, enzymes produced by bacteria that may inactivate ampicillin. * Treatment of infections caused by susceptible strains of Shigella, Salmonella, E. Coli, Haemophilus influenza, S. typhosa, N. Gonorrhea, enterococci, gram-positive organisms * Meningitis caused by Neisseria meningitides| * Contraindicated with allergies to penicillins, cephalosporins, or other allergens. * Use cautiously with renal disorders.

* CNS: Lethargy,hallucinations, seizures * CV: Heart failure * GI: Glossitis, stomatitis, gastritis, soremouth, nausea, vomiting, diarrhea, abdominal pain, bloody diarrhea, enterocolitis, pseudo membranous colitis, nonspecific hepatitis * GU: Nephritis * Hematology: Anemia, thrombocytopenia, leukopenia, neutropenia, prolonged bleeding time * Hypersensitivity: Rash, fever, wheezing, anaphylaxis * Local: Pain, phlebitis, thrombosis * Other:Superinfection| * Assess patient for infection (vital signs, wound appearance, sputum, urine, stool, and WBCs) at beginning and through out therapy. Obtain a history before initiating therapy to determine previous use of and reactions to penicillins or cephalosporins. Persons with a negative history of penicillin sensitivity may still have an allergic response. * Obtain specimens for culture and sensitivity before therapy. First dose may be given before receiving results. * Observe patients for signs and symptoms of anaphylaxis (rash, pruritus, laryngeal edema, wheezing).

Discontinue the drug and notify the physician immediately if these occur. Keep epinephrine, an antihistamine, and resuscitation equipment close by in the event of an anaphylactic reaction. * Caution patient to notify physician if fever and diarrhea occur, especially if stool contains blood, pus, or mucus. Advise patient not to treat diarrhea without consulting healthcare professional. * May occur up to several weeks after discontinuation.